Special Projects Group
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Full-pipeline structural biology for external and academic partners
The Special Projects Group (SPG) at the NYSBC serves as a multidisciplinary research and technology development team focused on solving challenging problems in structural biology. By integrating expertise across X-ray crystallography, cryo-electron microscopy, biophysics, and protein science, SPG helps to accelerate scientific discovery and enable high-impact research programs.
SPG partners with academic investigators, government agencies, foundations, and pharmaceutical/biotechnology companies to address complex biological questions across human health and disease that benefit from advanced structural and mechanistic insight. Projects range from antibody-antigen structure determination to structure-guided therapeutic development, infectious disease research, and biodefense initiatives.
SPG leverages NYSBC’s state-of-the-art infrastructure to pursue projects spanning protein production, biophysical characterization, and high-resolution structural analysis of biological macromolecules and molecular complexes.
Services
X-ray crystallography structure determination
Cryo-electron microscopy structure determination
Structure-guided drug discovery
Antibody and biologic molecular characterization
Biophysical assay development
Experimental design and project planning
Capabilities
Protein expression and purification
Macromolecular crystallization
X-ray diffraction data collection and structure determination
Single-particle cryo-EM
Protein–protein interaction studies
Structure-guided therapeutic discovery
Inquiries
Researchers, collaborators, and industry partners interested in working with SPG are encouraged to contact the group to discuss potential collaborations and scientific services.
Ongoing Research Projects
Structural immunology and antibody discovery
Infectious disease research
Structure-guided therapeutic development
Biodefense and toxin countermeasure research
Structural biology using cryo-electron microscopy and X-ray crystallography
“Our partnership with NYSBC has yielded dozens of structural insights into antibody interactions with toxins and pathogens through multidisciplinary collaboration combining immunology, infectious diseases, and structural biology.”