Near UV Photo-Degradation of IgG1-Fc Promoted by His and Fe(III): Probing the Role of the Metal-Binding Pocket by Site-Directed Mutagenesis

Maribel Espinoza Ballesteros, Marcela Solis Rodriguez, Steve Seibold, Kevin P. Battaile, Scott Lovell, Thomas J. Tolbert, Christian Schöneich

Molecular Pharmaceutics

Enterovirus RNase L inhibiting RNAs are highly conserved with limited phylogenetic distribution

Samantha Zangari, Madeline Sherlock, Jeffrey Kieft

RNA

A structural bridge between dengue virus tandem xrRNAs facilitates coordination of exonuclease resistance

Elizabeth Spear, Zoe O'Donoghue, Steve L. Bonilla, Kevin P. Larsen, Madeline E. Sherlock, Jeffrey S. Kieft

mBio, Vol. 17, Issue 9

Structures of distinct human acetylcholinesterase tetramer forms in complex with synaptic anchoring proteins

Jonah Cheung, Akira Karasawa

Structure

Overcoming air–water interface-induced artifacts in cryo-EM with protein nanocrates

Matthew C. Jenkins, Daija Bobe, Jake D. Johnston, Jonah Cheung, Akira Karasawa, Christina M. Zimanyi, Ömer Dermanci, Collin T. McManus, M. G. Finn, Alex de Marco, Mykhailo Kopylov

Nature Methods, Vol. 23, Issue 9, Pages 1798-1804

Imaging large fields-of-view at high resolution in cryo-ET with square beam montaging

Eugene Y.D. Chua, Hamidreza Rahmani, James Zhen, Fabian Eisenstein, Yong Hyun Song, Jake D. Johnston, Hanyu Wang, Lambertus M. Alink, Mykhailo Kopylov, Chi-Min Ho, Danielle A Grotjahn, Alex de Marco

Distinct energetic blueprints diversify function of conserved protein folds

Malcolm L. Wells, Chenlin Lu, Daniel Sultanov, Kyle C. Weber, Erin Ahern, Zhen Gong, Ethan Chen, Anum Glasgow

Nature Chemistry, Vol. 18, Issue 8, Pages 1496-1506

Assembly and priming of the VPS4B AAA+ ATPase of the human ESCRT system

James Hurley, Yuchao Zhang, Shuixia Tan, Kevin Larsen, Sumin Kim, Lilah Byun, Isabella Alfonso

Direct Determination of Protein Rotational Diffusion Tensors and Generalized Order Parameters from Multifield 15N NMR Spin Relaxation

Justin P. Williams, Arthur G. Palmer

Journal of the American Chemical Society, Vol. 148, Issue 26, Pages 27030-27034

Enterovirus RNase L inhibiting RNAs are highly conserved with limited phylogenetic distribution

Samantha I. Zangari, Madeline E. Sherlock, Jeffrey S. Kieft

A bacteriophytochrome Pr/Pfr heterodimer studied through single-particle time-resolved cryo-electron microscopy

Prabin Karki, William C. Budell, Rohit Kannachel, David Menendez, Carolina Hernandez, Joshua H. Mendez, Shemiran Kanou, Manjeet Singh, Chavdar Slavov, Peter Schwander, Tek Narsingh Malla, Emina A. Stojković, Marius Schmidt

Communications Chemistry, Vol. 9, Issue 1

Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity

Jordan M Mancl, Wenguang G Liang, Nicholas L Bayhi, Hui Wei, William C Budell, Joshua H Mendez, Tobin R Sosnick, Bridget Carragher, Clinton S Potter, Wei-Jen Tang

eLife, Vol. 14

Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity

Jordan M Mancl, Wenguang G Liang, Nicholas L Bayhi, Hui Wei, William C Budell, Joshua H Mendez, Tobin R Sosnick, Bridget Carragher, Clinton S Potter, Wei-Jen Tang

eLife, Vol. 14

Crystal structure of Plasmodium vivax macrophage migration inhibitory factor

Aryana Nair, Matthew Lin, Arav Srivastava, Lijun Liu, Anne Cooper, Kevin Battaile, Elizabeth Harmon, Peter J. Myler, Bart L. Staker, Scott Lovell, Graham Chakafana, Oluwatoyin A. Asojo

Acta Crystallographica Section F Structural Biology Communications, Vol. 82, Issue 6, Pages 194-200

SCM-1/SCAMP Maintains Microdomain Boundaries and Cargo Sorting within the Endosomal System

Kam Shan Hu, Anne Norris, Wilmer Rodriguez-Polanco, Collin McManus, Inna A. Nikoronova, Geoffrey G. Hesketh, Anne-Claude Gingras, Maureen M. Barr, Barth D. Grant

Simultaneous single-cell profiling of the transcriptome and proteome

Xuling Xu, Monica Pia Caggiano, Malcolm L. Wells, Guizhi Sun, Sue Mei Lim, Dylan H. Multari, Scott A. Blundell, Nicolas Hartel, Rosa Viner, Jose M. Polo, Ralf Schittenhelm, Alex de Marco

Molecular insight into microtubule nucleation by the XMAP215/γ-TuRC module

Collin T. McManus, Sophie M. Travis, Philip D. Jeffrey, Rui Zhang, Sabine Petry

Nature Communications, Vol. 17, Issue 1

Structure-Guided Design of Calcium-Dependent Protein Kinase 1 Inhibitors for Cryptosporidiosis

Wissarut Wijitrmektong, Ryan Choi, Matthew A Hulverson, Lijun Liu, Anne Cooper, Kevin P Battaile, Elizabeth K Harmon, Denise Ann Dayao, Lauren Huerta, Saul Tzipori, Case W McNamara, Malina A Bakowski, Scott Lovell, Wesley C Van Voorhis, Gregory D Cuny

The Journal of Infectious Diseases

Structural analyses of Trichomonas vaginalis pyrophosphate-dependent phosphofructokinase (TvPPi-PFK)

Avery Chiu, Lijun Liu, Steve Seibold, Kevin Battaile, Justin Craig, Elizabeth Harmon, Sandhya Subramanian, Lisabeth Cron, Bart Staker, Peter J Myler, Scott Lovell, Wesley C. Van Voorhis, Graham Chakafana, Oluwatoyin A. Asojo

A hotspot phosphorylation site on SHP2 drives oncoprotein activation and drug resistance

Prashath Karunaraj, Remkes Scheele, Malcolm L. Wells, Ruchita Rathod, Ipek S. Gokulu, Sophia R. Abrahamson, Lila Taylor, Lamia Chowdhury, Abiha Kazmi, Weixiao Song, Peter V. Hornbeck, Jing Li, Anum Glasgow, Neil Vasan

Nature Communications, Vol. 17, Issue 1