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Special Projects Group Lab
The SPG Laboratory conducts collaborative and investigator-driven research aimed at understanding biological mechanisms at the molecular level. The laboratory combines structural, biochemical, and biophysical approaches to investigate protein structure and function.Research projects frequently integrate multiple technologies, allowing investigators to move from protein production and characterization through high-resolution structure determination and functional validation. This comprehensive workflow provides a powerful platform for both fundamental biological discovery and translational research applications.The laboratory maintains expertise across a broad range of structural biology methodologies and works closely with NYSBC core facilities to provide access to advanced instrumentation and specialized technical capabilities.Methods and CapabilitiesStructural BiologyX-ray crystallographySingle-particle cryo-electron microscopyStructural analysis of protein complexesProtein ScienceRecombinant protein expressionProtein purificationComplex assembly and characterizationProtein engineeringBiophysical CharacterizationMicroscale thermophoresis (MST)Protein–protein and protein–ligand interaction analysisLabel-free and fluorescence-based binding studiesProtein stability and thermal unfolding analysisResearch AreasStructural immunologyStructure-guided drug discoveryInfectious disease and biodefense researchMembrane protein structural biology
Special Projects Group
A full gene-to-structure pipeline, delivering protein production and structural biology expertise to outside investigators.