Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention

Stefan G. Krimmer, Nicole Bertoletti, Yoshihisa Suzuki, Luka Katic, Jyotidarsini Mohanty, Sheng Shu, Sangwon Lee, Irit Lax, Wei Mi, Joseph Schlessinger

Stefan Krimmer

The Winter-Spring 2027 EM Course

Electron microscopy in combination with image analysis is increasingly powerful in producing 3D structures of individual molecules and large macromolecular complexes that are unapproachable by other methods. This course is focused on the concepts and theories behind electron microscopy. 

William Conway Malone

Overcoming air-water interface-induced artifacts in Cryo-EM with protein nanocrates

Matthew C Jenkins, Daija Bobe, Jake D Johnston, Jonah Cheung, Akira Karasawa, Christina M Zimanyi, Ömer Dermanci, M.G. Finn, Alex de Marco, Mykhailo Kopylov

De novo computational RNA modeling into cryo-EM maps of large ribonucleoprotein complexes

Kalli Kappel, Shiheng Liu, Kevin P. Larsen, Georgios Skiniotis, Elisabetta Viani Puglisi, Joseph D. Puglisi, Z. Hong Zhou, Rui Zhao, Rhiju Das

Cryo-EM of a viral RNA and RNA-protein complex reveals how structural dynamics and novel tRNA mimicry combine to hijack host machinery

Steve L. Bonilla, Madeline E. Sherlock, Andrea MacFadden, Jeffrey S. Kieft

A generalizable scaffold-based approach for structure determination of RNAs by cryo-EM

Conner J Langeberg, Jeffrey S Kieft

Cryo-EM reveals an entangled kinetic trap in the folding of a catalytic RNA

Steve L. Bonilla, Quentin Vicens, Jeffrey S. Kieft