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Atomic-resolution structure, dynamics, and interactions

Nuclear magnetic resonance (NMR) spectroscopy reveals the atomic-resolution structure and dynamics of biomolecules in solution, providing direct insight into conformational transitions, binding mechanisms, and functional motions that static structures cannot capture. The technique is particularly powerful for characterizing flexible regions, transient interactions, and systems not amenable for crystallization, which makes it essential for understanding how proteins and nucleic acids function in their native cellular environment.

NYSBC’s NMR facility comprises eleven high-field spectrometers spanning 475 to 900 MHz, among the most extensive collections in the world. Multiple instruments and unique probe configurations—including the only 800 MHz MAS cryoprobe in North America and specialized systems for solid-state, solution-state, and hyperpolarized experiments—drive experiments that define what is technically feasible in structural NMR. The facility supports researchers pursuing fundamental questions in protein dynamics, RNA structure, molecular interactions, and materials characterization. Experienced staff consults on experimental design, data collection, and analysis.

NYSBC’s NMR program opens up advanced NMR methodology opportunities to researchers nationwide. Consortium member institutions receive scheduled time based on membership tier. The broader research community can obtain access through the NIH-funded National Center on Molecular Dynamics by NMR (CoMD/NMR), which provides proposal-based approvals, training, and technology dissemination.

User Resources

  • The NMR instruments are allocated to NYSBC Consortium institutions according to their membership level. The schedule is published 13 weeks in advance to allow sufficient time for planning and sample preparation. NYSBC affiliates of consortium institutions can request use of their scheduled institutional NMR time by contacting their institution’s NYSBC NMR representative or nmrscheduling@nysbc.org.

    General Notes for NMR Schedule

    • Look at this schedule with a reload of your browser window before coming to use time you believe was allocated to you.  Your allocation is governed by your institutional representative. If you believe your allocations are in error, please contact them first. Additional questions can be directed to nmrscheduling@nysbc.org.
       
    • For NYSBC NMR specific information, see General Facility Summary and Facility FAQs.
       
    • See NMR Access Accounting for detailed comments on relative waiting of NMR use by field strength.
       
    • 900_2 is converted between solids and liquids.
       
    • The 600 DNP is not part of a member institution’s normal NMR allocation. Users interested in the 600 DNP should contact nmrscheduling@nysbc.org.
       
    • Scheduled maintenance:
      • NMR fills, updates: Tuesdays 9:00 a.m. noon, unless otherwise specified.
      • Server backups: Mondays 10:00 a.m.–noon.
      • NMR computers full synchronization: Mondays 2:00 a.m. start.

11 high-field spectrometers. 475–900 MHz. The only 800 MHz MAS cryoprobe in North America.