Biography

Working as a Senior Scientist in the Special Projects Group at NYSBC, I manage structural biology research projects related to understanding fundamental mechanisms of human health and disease using techniques such as X-ray crystallography and single particle cryo-EM. My expertise covers the full gene-to-structure pipeline and we routinely express and purify recombinant target proteins of interest from bacterial, insect, and mammalian cell systems to understand protein structure at the atomic level. Outside of work my interests include traveling, art and culture related activities, piano, cooking, and trying authentic food from all over the world.

Publications

Structures of distinct human acetylcholinesterase tetramer forms in complex with synaptic anchoring proteins

Jonah Cheung, Akira Karasawa

Structure

2026 September

Structures of Distinct Human Acetylcholinesterase Tetramers Form in Complex with Synaptic Anchoring Proteins

Jonah Cheung, Akira Karasawa

2026 January

Overcoming air-water interface-induced artifacts in Cryo-EM with protein nanocrates

Matthew C Jenkins, Daija Bobe, Jake D Johnston, Jonah Cheung, Akira Karasawa, Christina M Zimanyi, Ömer Dermanci, M.G. Finn, Alex de Marco, Mykhailo Kopylov

2025 August

Crystal Structure of a Chimeric Antigen Receptor (CAR) scFv Domain Rearrangement Forming a VL-VL Dimer

Jonah Cheung, Shagun Wazir, David R. Bell, James N. Kochenderfer, Wayne A. Hendrickson, Philippe Youkharibache

CRYSTALS, Vol. 13, Issue 4, Pages 710

2023 January

ALS and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy

Olivia Harding, Chantell S. Evans, Junqiang Ye, Jonah Cheung, Tom Maniatis, Erika L.F. Holzbaur

2021 April

ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy

Olivia Harding, Chantell S. Evans, Junqiang Ye, Jonah Cheung, Tom Maniatis, Erika L. F. Holzbaur

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol. 118, Issue 24

2021 January

Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6

Jack R. McGuire, Stephanie M. Bester, Mark A. Guelta, Jonah Cheung, Caroline Langley, Mark D. Winemiller, Sue Y. Bae, Vanessa Funk, James M. Myslinski, Scott D. Pegan, Jude J. Height

CHEMICAL RESEARCH IN TOXICOLOGY, Vol. 34, Issue 3, Pages 804-816

2021 January

Structure of the Regulatory Cytosolic Domain of a Eukaryotic Potassium-Chloride Cotransporter.

Christina M. Zimanyi, Mo Guo, Arshad Mahmood, Wayne A. Hendrickson, David Hirsh, Jonah Cheung

Structure (London, England : 1993), Vol. 28, Issue 9, Pages 1051-1060.e4

2020 July

Effects of ALS-associated TANK binding kinase 1 mutations on protein-protein interactions and kinase activity.

Junqiang Ye, Jonah Cheung, Valeria Gerbino, Göran Ahlsén, Christina Zimanyi, David Hirsh, Tom Maniatis

Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, Issue 49, Pages 24517-24526

2019 November

Rate-limiting step in the decarbamoylation of acetylcholinesterases with large carbamoyl groups

Terrone L. Rosenberry, Jonah Cheung

CHEMICO-BIOLOGICAL INTERACTIONS, Vol. 308, Pages 392-395

2019 January

The structural and biochemical impacts of monomerizing human acetylcholinesterase

Stephanie M. Bester, Kaylin A. Adipietro, Vanessa L. Funk, James M. Myslinski, Nicholas D. Keul, Jonah Cheung, Paul T. Wilder, Zachary A. Wood, David J. Weber, Jude J. Height, Scott D. Pegan

PROTEIN SCIENCE, Vol. 28, Issue 6, Pages 1106-1114

2019 January

Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector <i>Anopheles gambiae</i> Reveals Basis of Insecticide Resistance

Jonah Cheung, Arshad Mahmood, Ravi Kalathur, Lixuan Liu, Paul R. Carlier

STRUCTURE, Vol. 26, Issue 1, Pages 130-136.e2

2018 January

Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI-6

Stephanie M. Bester, Mark A. Guelta, Jonah Cheung, Mark D. Winemiller, Su Y. Bae, James Myslinski, Scott D. Pegan, Jude J. Height

CHEMICAL RESEARCH IN TOXICOLOGY, Vol. 31, Issue 12, Pages 1405-1417

2018 January

Novel structural features drive DNA binding properties of Cmr, a CRP family protein in TB complex mycobacteria

Sridevi Ranganathan, Jonah Cheung, Michael Cassidy, Christopher Ginter, Janice D Pata, Kathleen A McDonough

NUCLEIC ACIDS RESEARCH, Vol. 46, Issue 1, Pages 403-420

2018 January

Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons

ELIFE

2017 January

Hopeahainol A is a reversible inhibitor at the acetylcholinesterase (AChE) peripheral site that inhibits enzyme activity with a novel higher order concentration dependence

JOURNAL OF NEUROCHEMISTRY

2017 January

Hopeahainol A binds reversibly at the acetylcholinesterase (AChE) peripheral site and inhibits enzyme activity with a novel higher order concentration dependence

Terrone L. Rosenberry, Patricia K. Martin, A. Jeremy Nix, Scott A. Wildman, Jonah Cheung, Scott A. Snyder, Ren Xiang Tan

CHEMICO-BIOLOGICAL INTERACTIONS, Vol. 259, Pages 78-84

2016 January

Structures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interface

Matthew C. Franklin, Michael J. Rudolph, Christopher Ginter, Michael S. Cassidy, Jonah Cheung

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, Vol. 84, Issue 9, Pages 1246-1256

2016 January