Michael Skinner

https://nysbc.org/people/michael-skinner

Unveiling molecular insights into the mechanism of activation of oncogenic phosphoinositide 3-kinase mutants

Stefan G. Krimmer, Joseph Schlessinger

https://doi.org/10.1073/pnas.2218237119

Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands

Maria-Elena Liosi, Joseph A. Ippolito, Sean P. Henry, Stefan G. Krimmer, Ana S. Newton, Kara J. Cutrona, Rene A. Olivarez, Jyotidarsini Mohanty, Joseph Schlessinger, William L. Jorgensen

http://www.scopus.com/inward/record.url?eid=2-s2.0-85129488253&partnerID=MN8TOARS

Elucidating the origin of long residence time binding for inhibitors of the metalloprotease thermolysin

Jonathan Cramer, Stefan G. Krimmer, Veronica Fridh, Tobias Wulsdorf, Robert Karlsson, Andreas Heine, Gerhard Klebe

http://www.scopus.com/inward/record.url?eid=2-s2.0-85019607617&partnerID=MN8TOARS

Methyl, ethyl, propyl, butyl: Futile but not for water, as the correlation of structure and thermodynamic signature shows in a congeneric series of thermolysin inhibitors

Stefan G. Krimmer, Michael Betz, Andreas Heine, Gerhard Klebe

http://www.scopus.com/inward/record.url?eid=2-s2.0-84898006931&partnerID=MN8TOARS

Rational Design of Thermodynamic and Kinetic Binding Profiles by Optimizing Surface Water Networks Coating Protein-Bound Ligands

Stefan G. Krimmer, Jonathan Cramer, Michael Betz, Veronica Fridh, Robert Karlsson, Andreas Heine, Gerhard Klebe

http://www.scopus.com/inward/record.url?eid=2-s2.0-85003422164&partnerID=MN8TOARS

Adding a Hydrogen Bond May Not Help: Naphthyridinone vs Quinoline Inhibitors of Macrophage Migration Inhibitory Factor

Thomas K. Dawson, Pawel Dziedzic, Michael J. Robertson, José A. Cisneros, Stefan G. Krimmer, Ana S. Newton, Julian Tirado-Rives, William L. Jorgensen

http://www.scopus.com/inward/record.url?eid=2-s2.0-85038362000&partnerID=MN8TOARS

Conversion of a False Virtual Screen Hit into Selective JAK2 JH2 Domain Binders Using Convergent Design Strategies

Sean P. Henry, Maria-Elena Liosi, Joseph A. Ippolito, Kara J. Cutrona, Stefan G. Krimmer, Ana S. Newton, Joseph Schlessinger, William L. Jorgensen

http://www.scopus.com/inward/record.url?eid=2-s2.0-85129498237&partnerID=MN8TOARS

Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention

Stefan G. Krimmer, Nicole Bertoletti, Yoshihisa Suzuki, Luka Katic, Jyotidarsini Mohanty, Sheng Shu, Sangwon Lee, Irit Lax, Wei Mi, Joseph Schlessinger

https://doi.org/10.1073/pnas.2300054120

How Nothing Boosts Affinity: Hydrophobic Ligand Binding to the Virtually Vacated S<sub>1</sub>′ Pocket of Thermolysin

Stefan G. Krimmer, Jonathan Cramer, Johannes Schiebel, Andreas Heine, Gerhard Klebe

http://www.scopus.com/inward/record.url?eid=2-s2.0-85026843735&partnerID=MN8TOARS

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