Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment

Marco C. Miotto, Gunnar Weninger, Haikel Dridi, Qi Yuan, Yang Liu, Anetta Wronska, Zephan Melville, Leah Sittenfeld, Steven Reiken, Andrew R. Marks

Science Advances, Vol. 8, Issue 29

A drug and ATP binding site in type 1 ryanodine receptor

Zephan Melville, Haikel Dridi, Qi Yuan, Steven Reiken, Anetta Wronska, Yang Liu, Oliver B. Clarke, Andrew R. Marks

Structure, Vol. 30, Issue 7, Pages 1025-1034.e4

RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation.

Qi Yuan, Haikel Dridi, Oliver B. Clarke, Steven Reiken, Zephan Melville, Anetta Wronska, Alexander Kushnir, Ran Zalk, Leah Sittenfeld, Andrew R. Marks

Acta neuropathologica communications, Vol. 9, Issue 1

Investigating gating mechanisms of ion channels using temperature-resolved cryoEM.

Harsh Bansia, Claudio Catalano, Zephan Melville, Youzhong Guo, Andrew R. Marks, Amedee des Georges

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, Vol. 27, Issue S1, Pages 1690-1694

High resolution structure of the membrane embedded skeletal muscle ryanodine receptor

Zephan Melville, Kookjoo Kim, Oliver B. Clarke, Andrew R. Marks

Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target.

Haikel Dridi, Alexander Kushnir, Ran Zalk, Qi Yuan, Zephan Melville, Andrew R. Marks

Nature reviews. Cardiology, Vol. 17, Issue 11, Pages 732-747

Intracellular calcium leak as a therapeutic target for RYR1-related myopathies.

Alexander Kushnir, Joshua J. Todd, Jessica W. Witherspoon, Qi Yuan, Steven Reiken, Harvey Lin, Ross H. Munce, Benjamin Wajsberg, Zephan Melville, Oliver B. Clarke, Kaylee Wedderburn-Pugh, Anetta Wronska, Muslima S. Razaqyar, Irene C. Chrismer, Monique O. Shelton, Ami Mankodi, Christopher Grunseich, Mark A. Tarnopolsky, Kurenai Tanji, Michio Hirano, Sheila Riazi, Natalia Kraeva, Nicol C. Voermans, Angela Gruber, Carolyn Allen, Katherine G. Meilleur, Andrew R. Marks

Acta neuropathologica, Vol. 139, Issue 6, Pages 1089-1104

Ssd1 and the cell wall integrity pathway promote entry, maintenance, and recovery from quiescence in budding yeast.

Shawna Miles, Li Hong Li, Zephan Melville, Linda L. Breeden

Molecular biology of the cell, Vol. 30, Issue 17, Pages 2205-2217

Loss of S100A1 expression leads to Ca2+ release potentiation in mutant mice with disrupted CaM and S100A1 binding to CaMBD2 of RyR1.

Erick O. Hernández-Ochoa, Zephan Melville, Camilo Vanegas, Kristen M. Varney, Paul T. Wilder, Werner Melzer, David J. Weber, Martin F. Schneider

Physiological reports, Vol. 6, Issue 15, Pages e13822

The Activation of Protein Kinase A by the Calcium-Binding Protein S100A1 Is Independent of Cyclic AMP

Zephan Melville, Erick O. Hernández-Ochoa, Stephen J. P. Pratt, Yewei Liu, Adam D. Pierce, Paul T. Wilder, Kaylin A. Adipietro, Daniel H. Breysse, Kristen M. Varney, Martin F. Schneider, David J. Weber

Biochemistry, Vol. 56, Issue 17, Pages 2328-2337

Crystal structure of the human heterogeneous ribonucleoprotein A18 RNA-recognition motif.

Katherine Coburn, Zephan Melville, Ehson Aligholizadeh, Braden M. Roth, Kristen M. Varney, France Carrier, Edwin Pozharski, David J. Weber

Acta crystallographica. Section F, Structural biology communications, Vol. 73, Issue 4, Pages 209-214

X-ray crystal structure of human calcium-bound S100A1.

Zephan Melville, Ehson Aligholizadeh, Laura E. McKnight, Dylan J. Weber, Edwin Pozharski, David J. Weber

Acta crystallographica. Section F, Structural biology communications, Vol. 73, Issue 4, Pages 215-221

Novel protein-inhibitor interactions in site 3 of Ca(2+)-bound S100B as discovered by X-ray crystallography.

Michael C. Cavalier, Zephan Melville, Ehson Aligholizadeh, E. Prabhu Raman, Wenbo Yu, Lei Fang, Milad Alasady, Adam D. Pierce, Paul T. Wilder, Alexander D. MacKerell, David J. Weber

Acta crystallographica. Section D, Structural biology, Vol. 72, Issue 6, Pages 753-760

Key events during the transition from rapid growth to quiescence in budding yeast require posttranscriptional regulators.

Lihong Li, Shawna Miles, Zephan Melville, Amalthiya Prasad, Graham Bradley, Linda L. Breeden

Molecular biology of the cell, Vol. 24, Issue 23, Pages 3697-3709