Distinct energetic blueprints diversify function of conserved protein folds

Malcolm L. Wells, Chenlin Lu, Daniel Sultanov, Kyle C. Weber, Erin Ahern, Zhen Gong, Ethan Chen, Anum Glasgow

Nature Chemistry, Vol. 18, Issue 8, Pages 1496-1506

Simultaneous single-cell profiling of the transcriptome and proteome

Xuling Xu, Monica Pia Caggiano, Malcolm L. Wells, Guizhi Sun, Sue Mei Lim, Dylan H. Multari, Scott A. Blundell, Nicolas Hartel, Rosa Viner, Jose M. Polo, Ralf Schittenhelm, Alex de Marco

A hotspot phosphorylation site on SHP2 drives oncoprotein activation and drug resistance

Prashath Karunaraj, Remkes Scheele, Malcolm L. Wells, Ruchita Rathod, Ipek S. Gokulu, Sophia R. Abrahamson, Lila Taylor, Lamia Chowdhury, Abiha Kazmi, Weixiao Song, Peter V. Hornbeck, Jing Li, Anum Glasgow, Neil Vasan

Nature Communications, Vol. 17, Issue 1

Bidirectional allosteric ligand regulation in a central glycolytic enzyme

Belen Sundberg, Chenlin Lu, Malcolm L Wells, Kyle C Weber, Zhen Gong, Anum Glasgow

Site-resolved energetic information from HX–MS experiments

Chenlin Lu, Malcolm L. Wells, Andrew Reckers, Savannah K. McBride, Anum Glasgow

Nature Chemical Biology, Vol. 22, Issue 2, Pages 307-317

Prefusion structure, evasion and neutralization of HSV-1 glycoprotein B

Ryan S. Roark, Andrew J. Schaub, Wei Shi, Maple Wang, Fabiana A. Bahna, Jordan E. Becker, Andrea Biju, Sue Chong, Haijuan Du, Yicheng Guo, Hsiang Hong, Phinikoula S. Katsamba, Seetha M. Mannepalli, Adam S. Olia, Li Ou, Sarah K. Rubin, Yosef Sabo, Mehin Suleiman, Malcolm L. Wells, Baoshan Zhang, Cheng Cheng, Anum Glasgow, David D. Ho, Yaoxing Huang, Theodore C. Pierson, Reda Rawi, Tongqing Zhou, Lawrence Shapiro, Peter D. Kwong

Nature Microbiology, Vol. 10, Issue 11, Pages 2966-2980

Distinct energetic blueprints diversify function of conserved protein folds

Malcolm L. Wells, Chenlin Lu, Daniel Sultanov, Kyle C. Weber, Erin Ahern, Zhen Gong, Ethan Chen, Anum Glasgow

Site-resolved energetic information from HX/MS experiments

Chenlin Lu, Malcolm L. Wells, Andrew Reckers, Anum Glasgow

Ligand-specific changes in conformational flexibility mediate long-range allostery in the lac repressor

Anum Glasgow, Helen T. Hobbs, Zion R. Perry, Malcolm L. Wells, Susan Marqusee, Tanja Kortemme

Nature Communications, Vol. 14, Issue 1