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Biography

My mission as a scientist at NYSBC is to use structural biology to further our fundamental understanding of biology and chemistry. I contribute expertise in biochemistry and enzymology and more than a decade's experience in macromolecular structure solution to help SEMC staff and external users employ structural biology methods effectively in their research. My specialized interests include electron diffraction, metalloenzymes, pi-helices, nerdy jokes, and good bagels.

Publications

Applying 3D ED/MicroED workflows toward the next frontiers

Mahira Aragon, Sarah E. J. Bowman, Chun-Hsing Chen, M. Jason de la Cruz, Daniel A. Decato, Edward T. Eng, Kristen M. Flatt, Sahil Gulati, Yuchen Li, Charles J. Lomba, Brandon Mercado, Jessalyn Miller, Lukáš Palatinus, William J. Rice, David Waterman, Christina M. Zimanyi

Acta Crystallographica Section C Structural Chemistry, Vol. 80, Issue 6, Pages 179-189

2024 June

Cryo-EM sample preparation for high-resolution structure studies.

Liguo Wang, Christina M. Zimanyi

Acta crystallographica. Section F, Structural biology communications, Vol. 80, Issue 4, Pages 74-81

2024 March

Better, Faster, Cheaper: Recent Advances in Cryo–Electron Microscopy

Eugene Y.D. Chua, Joshua H. Mendez, Micah Rapp, Serban L. Ilca, Yong Zi Tan, Kashyap Maruthi, Huihui Kuang, Christina M. Zimanyi, Anchi Cheng, Edward T. Eng, Alex J. Noble, Clinton S. Potter, Bridget Carragher

Annual Review of Biochemistry, Vol. 91, Issue 1, Pages 1-32

2022 June

Broadening access to cryoEM through centralized facilities

Christina M. Zimanyi, Mykhailo Kopylov, Clinton S. Potter, Bridget Carragher, Edward T. Eng

Trends in Biochemical Sciences, Vol. 47, Issue 2, Pages 106-116

2022 January

Structure of the Regulatory Cytosolic Domain of a Eukaryotic Potassium-Chloride Cotransporter.

Christina M. Zimanyi, Mo Guo, Arshad Mahmood, Wayne A. Hendrickson, David Hirsh, Jonah Cheung

Structure (London, England : 1993), Vol. 28, Issue 9, Pages 1051-1060.e4

2020 July

Effects of ALS-associated TANK binding kinase 1 mutations on protein-protein interactions and kinase activity.

Junqiang Ye, Jonah Cheung, Valeria Gerbino, Göran Ahlsén, Christina Zimanyi, David Hirsh, Tom Maniatis

Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, Issue 49, Pages 24517-24526

2019 November

Unique structural features in an Nramp metal transporter impart substrate-specific proton cotransport and a kinetic bias to favor import.

Aaron T. Bozzi, Lukas B. Bane, Christina M. Zimanyi, Rachelle Gaudet

The Journal of general physiology, Vol. 151, Issue 12, Pages 1413-1429

2019 October

Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter.

Aaron T Bozzi, Christina M Zimanyi, John M Nicoludis, Brandon K Lee, Casey H Zhang, Rachelle Gaudet

eLife, Vol. 8

2019 February

A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases.

Niels Bradshaw, Vladimir M Levdikov, Christina M Zimanyi, Rachelle Gaudet, Anthony J Wilkinson, Richard Losick

eLife, Vol. 6

2017 May

Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli.

Christina M Zimanyi, Percival Yang-Ting Chen, Gyunghoon Kang, Michael A Funk, Catherine L Drennan

eLife, Vol. 5

2016 January

Novel mutations highlight the key role of the ankyrin repeat domain in TRPV4-mediated neuropathy.

Jeremy M. Sullivan, Christina M. Zimanyi, William Aisenberg, Breanne Bears, Dong-Hui Chen, John W. Day, Thomas D. Bird, Carly E. Siskind, Rachelle Gaudet, Charlotte J. Sumner

Neurology. Genetics, Vol. 1, Issue 4

2015 October

Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase.

Christina M. Zimanyi, Nozomi Ando, Edward J. Brignole, Francisco J. Asturias, JoAnne Stubbe, Catherine L. Drennan

Structure (London, England : 1993), Vol. 20, Issue 8, Pages 1374-1383

2012 June

The prototypic class Ia ribonucleotide reductase from Escherichia coli: still surprising after all these years.

Edward J. Brignole, Nozomi Ando, Christina M. Zimanyi, Catherine L. Drennan

Biochemical Society transactions, Vol. 40, Issue 3, Pages 523-530

2012 June

Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase.

Nozomi Ando, Edward J. Brignole, Christina M. Zimanyi, Michael A. Funk, Kenichi Yokoyama, Francisco J. Asturias, JoAnne Stubbe, Catherine L. Drennan

Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 52, Pages 21046-21051

2011 December

Polysialic acid governs T-cell development by regulating progenitor access to the thymus.

Penelope M. Drake, Christina M. Stock, Jay K. Nathan, Phung Gip, Kevin P. K. Golden, Birgit Weinhold, Rita Gerardy-Schahn, Carolyn R. Bertozzi

Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 29, Pages 11995-12000

2009 July

Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses.

Penelope M. Drake, Jay K. Nathan, Christina M. Stock, Pamela V. Chang, Marcus O. Muench, Daisuke Nakata, J Rachel Reader, Phung Gip, Kevin P. K. Golden, Birgit Weinhold, Rita Gerardy-Schahn, Frederic A. Troy, Carolyn R. Bertozzi

Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 10, Pages 6850-6858

2008 November