Special Projects Publications
2020
Zimanyi C, Guo M, Mahmood A, Hendrickson W, Hirsh D, Cheung J, Structure of the Regulatory Cytosolic Domain of a Eukaryotic Potassium-Chloride Cotransporter, Structure (2020), https://doi.org/10.1016/j.str.2020.06.009. Link
2019
Ye J, Cheung J, Gerbino V, Ahlsén G, Zimanyi C, Hirsh D, Maniatis T, Effects of ALS-associated TANK binding kinase 1 mutations on protein-protein interactions and kinase activity. Proc Natl Acad Sci U S A. 2019 Nov 20. pii: 201915732. doi: 10.1073/pnas.1915732116. [Epub ahead of print] PMID: 31748271. Link
Bester SM, Adipietro KA, Funk VL, Myslinski JM, Keul ND, Cheung J, Wilder PT, Wood ZA, Weber DJ, Height JJ, Pegan SD. The structural and biochemical impacts of monomerizing human acetylcholinesterase. PMID: 30993792. Protein Sci. 2019 Jun;28(6):1106-1114. doi: 10.1002/pro.3625. Epub 2019 May 3. Link
2018
Bester SM, Guelta MA, Cheung J, Winemiller MD, Bae SY, Myslinski J, Pegan SD, Height JJ. Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI-6. PMID: 30462502. Chem Res Toxicol. 2018 Dec 17;31(12):1405-1417. doi: 10.1021/acs.chemrestox.8b00294. Epub 2018 Dec 4. Link
Rudolph MJ, Vance DJ, Kelow S, Angalakurthi SK, Nguyen S, Davis SA, Rong Y, Middaugh CR, Weis DD, Dunbrack R Jr, Karanicolas J, Mantis NJ. Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity. Protein Eng Des Sel. 2018 Sep 28. doi: 10.1093/protein/gzy022. [Epub ahead of print] PMID: 30265352. Link
2017
Cheung J, Mahmood A, Kalathur R, Liu L, Carlier PR. Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance. Structure. doi:10.1016/j.str.2017.11.021. PMID: 29276037. Link
Sridevi Ranganathan, Jonah Cheung, Michael Cassidy, Christopher Ginter, Janice D. Pata, Kathleen A. McDonough. Novel structural features drive DNA binding properties of Cmr, a CRP family protein in TB complex mycobacteria. Nucleic Acids Research. doi:10.1093/nar/gkx1148. PMID: PMC5758884. Link
Bazzoli A, Vance DJ, Rudolph MJ, Rong Y, Angalakurthi SK, Toth RT 4th, Middaugh CR, Volkin DB, Weis DD, Karanicolas J, Mantis NJ. Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies. Proteins. 2017 Nov;85(11):1994-2008. doi: 10.1002/prot.25353. Epub 2017 Aug 4. PMID: 28718923. Link
Rudolph MJ, Vance DJ, Cassidy MS, Rong Y, Mantis NJ. Structural Analysis of Single Domain Antibodies Bound to a Second Neutralizing Hot Spot on Ricin Toxin’s Enzymatic Subunit. J Biol Chem. 2017 Jan 20;292(3):872-883. PMID: 27903650. Link
2016
Franklin MC, Rudolph MJ, Ginter C, Cassidy MS, Cheung J. Structures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interface. Proteins. 2016 Sep;84(9):1246-56. PMID: 27191504. Link
Rudolph MJ, Vance DJ, Cassidy MS, Rong Y, Shoemaker CB, Mantis NJ. Structural analysis of nested neutralizing and non-neutralizing B cell epitopes on ricin toxin’s enzymatic subunit. Proteins. 2016 Aug;84(8):1162-72. PMID: 27159829. Link
2015
Franklin MC, Cheung J, Rudolph MJ, Burshteyn F, Cassidy M, Gary E, Hillerich B, Yao ZK, Carlier PR, Totrov M, Love JD. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins. 2015 Dec;83(12):2124-36. PubMed PMID: 26033498. Link
Cheung J, Ginter C, Cassidy M, Franklin MC, Rudolph MJ, Robine N, Darnell RB, Hendrickson WA. Structural insights into mis-regulation of protein kinase A in human tumors. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1374-9. doi: 10.1073/pnas.1424206112. Epub 2015 Jan 20. PubMed PMID: 25605907; PubMed Central PMCID: PMC4321305. Link
2014
Rudolph MJ, Vance DJ, Cheung J, Franklin MC, Burshteyn F, Cassidy MS, Gary EN, Herrera C, Shoemaker CB, Mantis NJ. Crystal structures of ricin toxin’s enzymatic subunit (RTA) in complex with neutralizing and non-neutralizing single-chain antibodies. J Mol Biol. 2014 Aug 26;426(17):3057-68. doi: 10.1016/j.jmb.2014.05.026. Epub 2014 Jun 4. PubMed PMID: 24907552; PubMed Central PMCID: PMC4128236. Link
Cheung J, Beri V, Shiomi K, Rosenberry TL. Acetylcholinesterase complexes with the natural product inhibitors dihydrotanshinone I and territrem B: binding site assignment from inhibitor competition and validation through crystal structure determination. J Mol Neurosci. 2014 Jul;53(3):506-10. doi: 10.1007/s12031-014-0261-3. Epub 2014 Feb 27. Review. PubMed PMID: 24573600. Link
2013
Chaudhury, S., Abdulhameed, M. D. M., Singh, N., Tawa, G. J., D’haeseleer, P. M., Zemla, A. T., Navid, A., Zhou, C. E., Franklin, M. C., Cheung, J., Rudolph, M. J., Love, J., Graf, J. F., Rozak, D. A., Dankmeyer, J. L., Amemiya, K., Daefler, S., & Wallqvist, A. (2013). Rapid countermeasure discovery against Francisella tularensis based on a metabolic network reconstruction. PLoS One, 8, e63369. PMID: 23704901. Link
Cheung, J., Gary, E. N., Shiomi, K., & Rosenberry, T. L. (2013). Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility. ACS Medicinal Chemistry Letters, 4, 1091-1096. PMID: 24900610. Link
2012
Cheung, J., Rudolph, M. J., Burshteyn, F., Cassidy M. S., Gary, E. N., Love, J., Franklin M. C., & Height, J. J. (2012). Structures of human acetylcholinesterase in complex with pharmacologically important ligands. Journal of Medicinal Chemistry, 55, 10282-10286. PMID: 23035744. Link