Rapid Anti-Bacterial Drug Discovery

Researchers at NYSBC determined the crystal structures of three enzymes critical for the growth and survival of Francisella tularensis, a naturally-occurring pathogen that causes tularemia, a potentially fatal disease.

NYSBC structures were used in the development of novel antibiotics

Working with colleagues at the Department of Defense and Lawrence Livermore National Laboratory, NYSBC developed candidate drug molecules that inhibited these enzymes and thus blocked the growth of the bacterium. One of these inhibitors, compound 24, is shown below.

Research article: Chaudhury et al. PLoS ONE 8:e63369 (2013)