Research at NYSBC for Therapeutics and Vaccines for COVID-19  

From the early days of the COVID-19 pandemic, NYSBC has been providing researchers with high-resolution structures critical for the development of therapeutics and vaccines for combatting COVID-19.  The following papers all relied on the collection of high resolution cryo-EM data at NYSBC’s National Center for CryoEM Access and Training (NCCAT) and its Simons Electron Microscopy Center (SEMC).

 

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike. Nature. 2020. Lihong Liu, Pengfei Wang, Manoj S. Nair, Jian Yu, Micah Rapp, Qian Wang, Yang Luo, Jasper F.-W. Chan, Vincent Sahi, Amir Figueroa, Xinzheng V. Guo, Gabriele Cerutti, Jude Bimela, Jason Gorman, Tongqing Zhou, Zhiwei Chen, Kwok-Yung Yuen, Peter D. Kwong, Joseph G. Sodroski, Michael T. Yin, Zizhang Sheng, Yaoxing Huang, Lawrence Shapiro & David D. Ho. (link)

Controlling the SARS-CoV-2 spike glycoprotein conformation. Nature. 2020. Rory Henderson, Robert J. Edwards, Katayoun Mansouri, Katarzyna Janowska, Victoria Stalls, Sophie M. C. Gobeil, Megan Kopp, Dapeng Li, Rob Parks, Allen L. Hsu, Mario J. Borgnia, Barton F. Haynes & Priyamvada Acharya. (link)

Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex. Cell. 2020. James Chen, Brandon Malone, Eliza Llewellyn, Michael Grasso, Patrick M.M. Shelton, Paul Dominic B. Olinares, Kashyap Maruthi, Edward T. Eng, Hasan Vatandaslar, Brian T. Chait, Tarun M. Kapoor, Seth A. Darst, Elizabeth A. Campbell. (link)

Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes. 2020. Tongqing Zhou, I-Ting Teng, Adam S. Olia, Gabriele Cerutti, Jason Gorman, Alexandra Nazzari, Wei Shi, Yaroslav Tsybovsky, Lingshu Wang, Shuishu Wang, Baoshan Zhang, Yi Zhang, Phinikoula S. Katsamba, Yuliya Petrova, Bailey B. Banach, Ahmed S. Fahad, Lihong Liu, Sheila N. Lopez Acevedo, Bharat Madan, Matheus Oliveira de Souza, Xiaoli Pan, Pengfei Wang, Jacy R. Wolfe, Michael Yin, David D. Ho, Emily Phung, Anthony DiPiazza, Lauren Chang, Olubukula Abiona, Kizzmekia S. Corbett, Brandon J. DeKosky, Barney S. Graham, John R. Mascola, John Misasi, Tracy Ruckwardt, Nancy J. Sullivan, Lawrence Shapiro, Peter D. Kwong. (link)

Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis. 2020. Natalia G. Herrera, Nicholas C. Morano,  Alev Celikgil, George I. Georgiev, Ryan J. Malonis, James H. Lee, Karen Tong, Olivia Vergnolle, Aldo B. Massimi, Laura Y. Yen, Alex J. Noble, Mykhailo Kopylov, Jeffrey B. Bonanno, Sarah C. Garrett-Thomson, David B. Hayes, Robert H. Bortz III,  Ariel S. Wirchnianski, Catalina Florez, Ethan Laudermilch, Denise Haslwanter, J. Maximilian Fels, M. Eugenia Dieterle, Rohit K. Jangra, Jason Barnhill, Amanda Mengotto, Duncan Kimmel, Johanna P. Daily, Liise-anne Pirofski, Kartik Chandran, Michael Brenowitz, Scott J. Garforth, Edward T. Eng, Jonathan R. Lai, Steven C. Almo. (link)

A glycan cluster on the SARS-CoV-2 spike ectodomain is recognized by Fab-dimerized glycan-reactive antibodies. 2020. Priyamvada Acharya, Wilton Williams, Rory Henderson, Katarzyna Janowska, Kartik Manne, Robert Parks, Margaret Deyton, Jordan Sprenz, Victoria Stalls, Megan Kopp, Katayoun Mansouri, Robert J Edwards, R. Ryan Meyerhoff, Thomas Oguin, Gregory Sempowski, Kevin Saunders, Barton F. Haynes. (link)