Combining X-ray, NMR, and EM

The Special Projects Group performs independent research at NYSBC.  They integrate multiple structural biology techniques available at the center, which uniquely allows them to address diverse biological problems.

About Special Projects Group

The Special Projects Group (SPG) is a team of expert scientists who use the combined structural biology resources available at NYSBC to understand fundamental mechanisms of neurological disease and cancer; aid in drug design, and develop therapeutics and vaccines through antibody epitope mapping and antibody engineering.  The SPG is independently funded through research agreements and contracts.  Current and past funding agencies include: the National Institute of Allergy and Infectious Diseases (NIAID); the Simons Foundation; Takeda Pharmaceuticals; and the Department of Defense.  The SPG also performs structure determination and protein production on a fee-for-service basis for diverse laboratories in academia, government, and at pharmaceutical companies and biotechnology start-ups.  This talented group of scientists has expertise in the entire X-ray crystallography gene-to-structure pipeline as well as in Cryoelectron Microscopy, and works closely with NYSBC’s NMR Department and Simons Electron Microscopy Center for structure determination and protein characterization.

The Special Projects Group has successfully completed numerous projects for a wide range of purposes, including:

  • Structural elucidation of novel drug targets
  • Determining the consequences of cancer mutations
  • Optimizing antibodies
  • Designing new vaccines
  • Identifying new antibiotics
  • Producing high quality protein for experimental purposes