The NMR Department at NYSBC pursues challenging problems in structural biology and materials science. The facility is supported by experienced staff dedicated to providing hands-on-training in data collection and available for consultation on individual projects. The NMR department also houses the NIH National Center on Molecular Dynamics by NMR (COMD/NMR) which focuses on making NMR methodologies for characterizing protein and nucleic acid conformational dynamics available to the wider biological research community.
Capabilities
- Access to six high field magnets (800-900 MHz) with solution and solid-state NMR capabilities.
- Applications of Dynamic Nuclear polarization in the study of biomolecules and materials science.
- Staff expertise in structural and dynamic characterization of high molecular weight proteins, nucleic acids and complexes.
- Pulse sequence development for specific applications in solution and solid-state study of molecular dynamics by NMR and simulations.
- Sample Jet with automation for metabolomics and high throughput drug screening.
- Hands-on-training
- Workshops on data processing and analysis.
- Theory course on NMR spin physics offered with Columbia University.

NMR – From protein to structure
Probing atomic level details of molecules using both Solution and Solid-State NMR techniques at a range of field strengths (500-900 MHz).
NMR Applications
- Chemical shift assignment of large proteins and nucleic acids.
- Chemical shift perturbation assays to probe binding. Structure determination of proteins, nucleic acids and complexes.
- In-cell NMR
- High-throughput screening of small molecules in drug discovery. Metabolomics
- Nuclear relaxation as a probe of biomolecular dynamics. Combining NMR data with SAXS/SANS and CryoEM to develop model structures of supra-molecular assemblies. Membrane protein structures in solution and micro-crystalline form by solid state NMR.