Special Projects Publications2018-07-20T15:32:13+00:00

Special Projects Publications

2017

Cheung J, Mahmood A, Kalathur R, Liu L, Carlier PR.  Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance.  Structure. doi:10.1016/j.str.2017.11.021.  PMID:  29276037.  Link

Sridevi Ranganathan, Jonah Cheung, Michael Cassidy, Christopher Ginter, Janice D. Pata, Kathleen A. McDonough.  Novel structural features drive DNA binding properties of Cmr, a CRP family protein in TB complex mycobacteria.  Nucleic Acids Research. doi:10.1093/nar/gkx1148.  PMID: PMC5758884.  Link

Bazzoli A, Vance DJ, Rudolph MJ, Rong Y, Angalakurthi SK, Toth RT 4th, Middaugh CR, Volkin DB, Weis DD, Karanicolas J, Mantis NJ. Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies.  Proteins. 2017 Nov;85(11):1994-2008. doi: 10.1002/prot.25353. Epub 2017 Aug 4.  PMID:  28718923.  Link

Rudolph MJ, Vance DJ, Cassidy MS, Rong Y, Mantis NJ. Structural Analysis of Single Domain Antibodies Bound to a Second Neutralizing Hot Spot on Ricin Toxin’s Enzymatic Subunit. J Biol Chem. 2017 Jan 20;292(3):872-883. PMID: 27903650. Link

2016

Franklin MC, Rudolph MJ, Ginter C, Cassidy MS, Cheung J. Structures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interface. Proteins. 2016 Sep;84(9):1246-56. PMID: 27191504. Link

Rudolph MJ, Vance DJ, Cassidy MS, Rong Y, Shoemaker CB, Mantis NJ. Structural analysis of nested neutralizing and non-neutralizing B cell epitopes on ricin toxin’s enzymatic subunit. Proteins. 2016 Aug;84(8):1162-72. PMID: 27159829. Link

2015

Franklin MC, Cheung J, Rudolph MJ, Burshteyn F, Cassidy M, Gary E, Hillerich B, Yao ZK, Carlier PR, Totrov M, Love JD. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins. 2015 Dec;83(12):2124-36. PubMed PMID: 26033498. Link

Cheung J, Ginter C, Cassidy M, Franklin MC, Rudolph MJ, Robine N, Darnell RB, Hendrickson WA. Structural insights into mis-regulation of protein kinase A in human tumors. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1374-9. doi: 10.1073/pnas.1424206112. Epub 2015 Jan 20. PubMed PMID: 25605907; PubMed Central PMCID: PMC4321305. Link

2014

Rudolph MJ, Vance DJ, Cheung J, Franklin MC, Burshteyn F, Cassidy MS, Gary EN, Herrera C, Shoemaker CB, Mantis NJ. Crystal structures of ricin toxin’s enzymatic subunit (RTA) in complex with neutralizing and non-neutralizing single-chain antibodies. J Mol Biol. 2014 Aug 26;426(17):3057-68. doi: 10.1016/j.jmb.2014.05.026. Epub 2014 Jun 4. PubMed PMID: 24907552; PubMed Central PMCID: PMC4128236. Link

Cheung J, Beri V, Shiomi K, Rosenberry TL. Acetylcholinesterase complexes with the natural product inhibitors dihydrotanshinone I and territrem B: binding site assignment from inhibitor competition and validation through crystal structure determination. J Mol Neurosci. 2014 Jul;53(3):506-10. doi: 10.1007/s12031-014-0261-3. Epub 2014 Feb 27. Review. PubMed PMID: 24573600. Link

2013

Chaudhury, S., Abdulhameed, M. D. M., Singh, N., Tawa, G. J., D’haeseleer, P. M., Zemla, A. T., Navid, A., Zhou, C. E., Franklin, M. C., Cheung, J., Rudolph, M. J., Love, J., Graf, J. F., Rozak, D. A., Dankmeyer, J. L., Amemiya, K., Daefler, S., & Wallqvist, A. (2013). Rapid countermeasure discovery against Francisella tularensis based on a metabolic network reconstruction. PLoS One, 8, e63369. PMID: 23704901. Link

Cheung, J., Gary, E. N., Shiomi, K., & Rosenberry, T. L. (2013). Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility. ACS Medicinal Chemistry Letters, 4, 1091-1096. PMID: 24900610. Link

2012

Cheung, J., Rudolph, M. J., Burshteyn, F., Cassidy M. S., Gary, E. N., Love, J., Franklin M. C., & Height, J. J. (2012). Structures of human acetylcholinesterase in complex with pharmacologically important ligands. Journal of Medicinal Chemistry, 55, 10282-10286. PMID: 23035744. Link