Structure & Function of the Bile acid transporter
Brian Kloss and Renato Bruni from NYCOMPS worked with Columbia University’s Ming Zhou, Matthias Quick and colleagues to elucidate the mechanism of transport of bile acids in the body. The groups cloned, expressed, and solved the X-ray crystal structure of ASBTYf, a close relative of the human protein that transports bile acids from the small intestine back to the bloodstream, where they are returned to the liver. This important function had not been previously understood.
A novel mechanism reveals how bile acids are recovered from the gut during normal digestion
Research article: Zhou et al. Nature 505:569 (2013).