New electron microscopy directors join NYSBC

January 16, 2015
Posted By: EM

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On January 1, 2015 Bridget Carragher and Clint Potter joined the New York Structural Biology Center (NYSBC) to direct the Electron Microscopy Group. Carragher and Potter joined the NYSBC after having directed the National Resource for Automated Molecular Microscopy at the Scripps Research Institute in La Jolla where they both served as professors for the last 13 years. One of their main research interests is the development of automated imaging techniques to enable the investigation of the structure, function and dynamics of molecular machines. They have developed a system, called Leginon, to automate and emulate all of the decisions and actions of a highly trained microscopist in collecting data by cryo-electron microscopy (cryo-EM).

Along with the move of Carragher and Potter to NYSBC, the National Resource for Automated Molecular Microscopy (NRAMM) has also moved to NYSBC. NRAMM is a National Biotechnology Research Resource whose mission is to develop, test and apply technology aimed towards completely automating the processes involved in solving macromolecular structure using cryo-EM. A main goal is to both serve as a center for high-throughput molecular imaging and to transfer this technology to the research community.

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Examples of structures solved at NRAMM over the past several years.

The NYSBC is a consortium of nine preeminent academic research institutions that provides advanced resources and tools in structural biology to its members and outside investigators. Founded in 2002, it was the first cooperative research center established in New York. Its main facility in Harlem hosts high-throughput protein production, cryo-electron microscopy, and nuclear magnetic resonance spectroscopy. A separate facility for X-ray crystallography is located at the National Synchrotron Light Source at Brookhaven National Laboratory in Long Island.

NYSBC is a leader in applying structural biological techniques to determine the three-dimensional structure of molecules and molecular assemblies in order to understand their role in cell behavior and disease mechanisms. The new Electron Microscopy Group (EMG) led by Carragher and Potter brings state of the art cryo-EM equipment and expertise to NYSBC. These new resources will strengthen scientific collaboration and foster novel research in the New York region.