Relaxation and Dynamics @NYSBC

ribonuclease H Backbone 15N order parameters for E. coli ribonuclease H are color coded from yellow (low) to violet (high) onto a backbone chain trace.

About Relaxation and Dynamics @NYSBC

Staff Scientists and affiliated researchers at NYSBC have extensive experience and broad research programs using NMR spectroscopy to characterize macromolecular conformational dynamics and kinetics linked to biological functions, including folding, binding, allosterism, and kinetics. Resources on this site are available to the research community to foster such investigations.

News and Events

  • New educational materials available: Tutorial on Model-free analysis of 15N relaxation data.
  • NMR Spectroscopy of Macromolecules to be taught Spring 2016.

Recent Publications

    KA Stafford, N Trbovic, JA Butterwick, R Abel, RA Friesner, and AG Palmer, Conformational preferences underlying reduced activity of a thermophilic ribonuclease H, J. Mol. Biol. 427, 853–866 (2015). doi: 10.1016/j.jmb.2014.11.023.
    LE Hough, K Dutta, S Sparks, DB Temel, A Kamal, J Tetenbaum-Novatt, MP Rout, D Cowburn, The molecular mechanism of nuclear transport revealed by atomic-scale measurements, Elife 4, e10027 (2015). doi: 10.7554/eLife.10027.