The NMR department at NYSBC is a shared resource that tackles challenging problems in structural biology and materials science. The facility is supported by experienced staff dedicated to providing hands-on-training in data collection and available for consultation on individual projects.
- Access to six high field magnets (800-900 MHz) with solution and solid state NMR capabilities.
- Applications of Dynamic Nuclear polarization in the study of biomolecules and materials science.
- Staff expertise in structural and dynamic characterization of high molecular weight proteins, nucleic acids and complexes.
- Pulse sequence development for specific applications in solution and solid state NMR.
- Study of molecular dynamics by NMR and simulations.
- Sample Jet with automation for metabolomics and high throughput drug screening.
- Hands on training.
- Workshops on data processing and analysis.
- Theory course on NMR spin physics offered with Columbia University.
- Chemical shift assignment of large proteins and nucleic acids.
- Chemical shift perturbation assays to probe binding.
- Structure determination of proteins, nucleic acids and complexes.
- In cell NMR
- High throughput screening of small molecules in drug discovery.
- Nuclear relaxation as a probe of biomolecular dynamics.
- Combining NMR data with SAXS/SANS and CryoEM to develop model structures of supra-molecular assemblies.
- Membrane protein structures in solution and micro-crystalline form by solid state NMR.